It depends on the publisher. There are some small publishers that don't require an agent for submission. Also, at times, a bigger publisher will have a time period when they open up for submissions. Sometimes, those will have types of subgenera specifications for what they want to see submitted. It will depend on the publisher. But they usually have their requirements listed, either way, in how to send things. Best to follow what they put on the submission page of the site.
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